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Keyan Zhu-Salzman

TITLE:  Associate Professor

EDUCATION:

  • B.S. Fudan University, China (1985)
  • M.S. Fudan University, China (1988)
  • Ph.D Purdue University (1994)

RESEARCH: Over millions of years of co-evolution with insects, plants have developed various defense machineries that can be activated in response to insect herbivory. Insects, in turn, have developed a variety of strategies to evade these plant defense mechanisms. An improved understanding of this complex plant defense and insect counter-defense relationship will facilitate development of better strategies to improve host plant defense. Currently, we are using Arabidopsis to study plant defense signal transduction pathways against insect pests. Meanwhile, since effectiveness of plant defense is also determined by the insect response, my laboratory is also investigating how insects adapt to the challenge of plant defense molecules, as well as to human imposed management strategies, and is working to identify new insect vulnerable systems.

TEACHING: I teach undergraduate courses: ENTO 428 (Insect Biotechnology) and ENTO 429 (Insect Biotechnology Laboratory).

Publications (* corresponding)

39. Ahn, J-E., L.A. Guarino and K. Zhu-Salzman* (2010) Coordination of Hepatocyte Nuclear Factor 4 and Seven-up Controls Insect Counter-Defense Cathepsin B Expression. J. Biol. Chem. (in press)

38. Chi, Y.H., Y.D. Koo, S.Y. Dai, J-E. Ahn, D-J. Yun, S.Y. Lee and K. Zhu-Salzman* (2010) Cowpea bruchid midgut transcriptome response to a soybean cystatin—costs and benefits of counter-defense. Comp. Biochem. Physiol. (in press)

37. Peters, L., K. Zhu-Salzman and T. Pankiw (2010) Effect of primer pheromones and pollen diet on the food producing glands of worker honey bees (Apis mellifera L.). J. Insect Physiol. 56: 132-137

36. Ahn, J-E. and K. Zhu-Salzman* (2009) CmCatD, a cathepsin D-like protease has a potential role in insect defense against a phytocystatin. J. Insect Physiol. 55: 678-685

35. Chi, Y.H., R.A. Salzman, S. Balfe, J-E. Ahn, W. Sun, J. Moon, D-J. Yun, S.Y. Lee, T.J.V. Higgins, B. Pittendrigh, L.L. Murdock and K. Zhu-Salzman* (2009) Cowpea bruchid midgut transcriptome response to a soybean cystatin—costs and benefits of counter-defense. Insect Mol. Biol. 18: 97-110

34. Zhu-Salzman, K.* and R.S. Zeng (2008) Molecular mechanisms of insect adaptation to plant defense—lessons learned from a bruchid beetle. Insect Sci. 15: 477-481

33. Koo, Y.D., J-E. Ahn, R.A. Salzman, J. Moon, Y.H. Chi, D-J. Yun, S.Y. Lee, H. Koiwa and K. Zhu-Salzman* (2008) Functional expression of an insect cathepsin B-like counter-defense protein. Insect Mol. Biol. 17:235-45

32. Zhu-Salzman, K., D.S. Luthe and G.W. Felton (2008) Arthropod-inducible proteins: Broad spectrum defenses against multiple herbivores.  Plant Physiol. 146: 852-858

31. Ahn, J-E., L.A. Guarino and K. Zhu-Salzman* (2007) Seven-up facilitates insect counter-defense by suppressing cathepsin B expression. FEBS J. 274: 2800-2814

30. Amirhusin, B., R.E. Shade, H. Koiwa, P.M. Hasegawa, R.A. Bressan, L.L. Murdock and K. Zhu-Salzman* (2007) Protease inhibitors from several classes work synergistically against Callosobruchus maculatus.  J. Insect Physiol. 53: 734-740

29. Ahn, J-E., M.R. Lovingshimer, R.A. Salzman, J.K. Presnail, A.L. Lu, H. Koiwa and K. Zhu-Salzman* (2007)  Cowpea bruchid Callosobruchus maculatus counteracts dietary protease inhibitors through modulating propeptides of major digestive enzymes. Insect Mol. Biol. 16: 295-304

28. Zhu-Salzman, K.* and L.L. Murdock (2006) Cowpea: insects, ecology and control. Invited article for the Encyclopedia of Pest Management, published by Marcel Dekker. pp1-3

27. Liu, Y., J-E. Ahn, S. Datta, R.A. Salzman, J. Moon, B. Huyghues-Despointes, B. Pittendrigh, L.L. Murdock, H. Koiwa and K. Zhu-Salzman* (2005) Arabidopsis vegetative storage protein is an anti-insect acid phosphatase. Plant Physiol. 139: 1545-1556

26. Sagili, R.R., T. Pankiw and K. Zhu-Salzman (2005) Effects of soybean trypsin inhibitor on hypopharyngeal gland protein content, total midgut protease activity and survival of the honey bee (Apis mellifera L.). J. Insect Physiol. 51: 953-957

25. Zhu-Salzman, K., J.L. Bi and T.X. Liu (2005) Molecular strategies of plant defense and insect counter-defense. Insect Science 12: 3-15

24. Liu, Y., R.A. Salzman, T. Pankiw and K. Zhu-Salzman* (2004) Transcriptional regulation in southern corn rootworm larvae challenged by soyacystatin N. Insect Biochem. Mol. Biol. 34: 1069-1077

23. Pankiw, T., R. Roman, R.R. Sagili, and K. Zhu-Salzman (2004) Pheromone-modulated behavioral suites influence colony growth in the honey bee (Apis mellifera). Naturwissenschaften 91: 575-578

22. Ahn, J-E., R.A. Salzman, S.C. Braunagel, H. Koiwa and K. Zhu-Salzman* (2004) Functional roles of specific bruchid protease isoforms in adaptation to a soybean protease inhibitor. Insect Mol. Biol. 13: 649-657

21. Moon, J., R.A. Salzman, J-E, Ahn, H. Koiwa and K. Zhu-Salzman* (2004) Transcriptional regulation in cowpea bruchid guts during adaptation to a plant defense protease inhibitor. Insect Mol. Biol. 13: 283-291

20. Amirhusin, B., R.E. Shade, H. Koiwa, P.M. Hasegawa, R.A. Bressan, L.L. Murdock and K. Zhu-Salzman* (2004) Soyacystatin N inhibits proteolysis of wheat a-amylase inhibitor and potentiates toxicity against cowpea bruchid, Callosobruchus maculates. J. Econ. Entomol. 97: 2095-2100

19. Zhu-Salzman, K.*, R.A. Salzman, J-E. Ahn and H. Koiwa (2004) Transcriptional regulation of sorghum defense determinants against a phloem-feeding aphid. Plant Physiol. 134: 420-431

18. Zhu-Salzman, K.*, H. Li , P.E. Klein and R.L. Gorena (2003) Using high-throughput amplified fragment length polymorphism to distinguish sorghum greenbug (Homoptera: Aphididae) biotypes. Agr. Forest Entomol. 5: 311-315 

17. Zhu-Salzman, K.*, H. Koiwa, R.A. Salzman, R.E. Shade and J-E. Ahn (2003) Cowpea bruchid Callosobruchus maculatus uses a three-component strategy to overcome a plant defensive cysteine protease inhibitor. Insect Mol. Biol. 12: 135-145

16. Zhu-Salzman, K.*, J-E. Ahn, R.A. Salzman, H. Koiwa, R.E. Shade and S. Balfe (2003) Fusion of a soybean cysteine protease inhibitor and a legume lectin enhances anti-insect activity synergistically. Agr. Forest Entomol. 5: 317-323

15. Zhu-Salzman, K.*, P.K. Hammen, R.A. Salzman, H. Koiwa, R.A. Bressan, L.L. Murdock and P.M. Hasegawa (2002) Calcium modulates protease resistance and carbohydrate binding of a plant defense legume lectin, Griffonia simplicifolia lectin II (GSII). Comp. Biochem. Physiol. 132: 327-334

14. Zhu-Salzman, K.* (2002) Book review for "Recombinant Protease Inhibitors in Plants". Ann. Entomol. Soc. Am. 95: 651

13. Zhu-Salzman, K.* and R.A. Salzman (2001) Functional mechanics of the plant defensive Griffonia simplicifolia lectin II: resistance to proteolysis is independent of glycoconjugate binding in the insect gut. J. Econ. Entomol. 94: 1280-1284

12. Koiwa, H., M.P. D'Urzo, I. Assfalg-Machleidt, K. Zhu-Salzman, R.E. Shade, H. An, L.L. Murdock, W. Machleidt, R.A. Bressan and P.M. Hasegawa (2001) Phage display selection of hairpin loop soyacystatin variants that mediate high affinity inhibition of a cysteine proteinase. Plant J. 27: 383-391

11. Koiwa, H., M.P. D'Urzo, K. Zhu-Salzman, J.I. Ibeas, R.E. Shade, L.L. Murdock, R.A. Bressan, P.M. Hasegawa (2000) An in-gel assay of a recombinant western corn rootworm (Diabrotica virgifera virgifera) cysteine proteinase expressed in yeast. Analytical Biochem. 282:153-155

10. Koiwa, H., R.E. Shade, K. Zhu-Salzman, M.P. D'Urzo, L.L. Murdock, R.A. Bressan and P.M. Hasegawa (2000) A plant defensive cystatin (soyacystatin) targets cathepsin L-like digestive cysteine proteinases (DvCALs) in the larval midgut of western corn rootworm (Diabrotica virgifera virgifera). FEBS Lett. 471:67-70

9. Salzman, R.A., T. Fujita, K. Zhu-Salzman, P.M. Hasegawa and R.A. Bressan (1999) An improved RNA isolation method for plant tissues containing high levels of phenolic compounds or carbohydrates. Plant Mol. Biol. Rep. 17:11-17

8. Zhu-Salzman, K., R.E. Shade, H. Koiwa, R.A. Salzman, M. Narasimhan, R.A. Bressan, P.M. Hasegawa and L.L. Murdock (1998)  Carbohydrate-binding and resistance to proteolysis control insecticidal activity of Griffonia simplicifolia lectin II (GS-II). Proc. Natl. Acad. Sci. USA 95: 15123-15128

7. Zhu-Salzman, K., R.A. Salzman, H. Koiwa, L.L. Murdock, R.A. Bressan and P.M. Hasegawa (1998) Ethylene negatively regulates local expression of plant defense lectin genes. Physiol Plant 104: 365-372

6. Koiwa, H., R.E. Shade, K. Zhu-Salzman, L. Subramanian, L.L. Murdock, S.S. Nielsen, R.A. Bressan and P.M. Hasegawa (1998) Phage display selection can differentiate insecticidal activity of soybean cystatins. Plant J. 14: 371-379

5. Koiwa, H., L. Subramanian, R.E. Shade, K. Zhu-Salzman, S.S. Nielsen, L.L. Murdock, R.A. Bressan and P.M. Hasegawa (1997) Insecticidal activities of soybean cysteine proteinase inhibitors are correlated with their papain-binding affinities as phage-displayed proteins. Plant Physiol. 114: S-220

4. Zhu-Salzman, K., R.A. Bressan, P.M. Hasegawa and L.L. Murdock (1996) Identification of N-acetylglucosamine binding residues in Griffonia simplicifolia lectin II. FEBS Lett. 390: 271-274

3. Zhu-Salzman, K., J.E. Huesing, R.E. Shade, R.A. Bressan, P.M. Hasegawa and L.L. Murdock (1996) An insecticidal N-acetylglucosamine-specific lectin gene from Griffonia simplicifolia (Leguminosae). Plant Physiol. 110: 195-202

2. Zhu-Salzman, K., L. Ke and J. Xin (1996) Selection and genetic analysis of fenvalerate-resistance in Amblyseius pseudolongispinosus (Acari: Phytoseiidae). Systematic and Applied Acarol. 1: 5-10

1. Zhu-Salzman, K., J.E. Huesing, R.E. Shade and L.L. Murdock (1994) Cowpea trypsin inhibitor and resistance to cowpea weevil (Coleoptera: Bruchidae) in cowpea variety 'TVu 2027'. Environ. Entomol. 23: 987-991

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